New form of materials can often enable new device and system applications. In this talk, I will highlight our group's recent work under this motivation in two synergistic areas. Firstly, by stacking individual layers of polymer, metal, and low-impedance coating reliably in a same nanomeshed pattern, the final multilayer multifunctional nanomeshes achieved system-level performance from all individual layers, in addition to nanomesh advantages. Compelling demonstrations from this multifunctional nanomesh approach include high-performance transparent and flexible neuroelectrode arrays, which has been recently validated in vivo. The second part of my talk will introduce our recent concept on semiconductor nanomeshes. By making a silicon film into homogeneous nanomeshes, we achieve high mobility semiconductor that is intrinsically stretchable to conventional microelectronic layouts. Together, our work demonstrates that nanomeshing is a unique way of transforming microelectronics for emerging applications.