| About this Abstract |
| Meeting |
Materials Science & Technology 2020
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
3D Printed Strontium-doped Alginate-collagen Scaffolds for Bone Tissue Engineering |
| Author(s) |
Shams Khondkar, Naomi M Edwards, Azhar Ilyas |
| On-Site Speaker (Planned) |
Shams Khondkar |
| Abstract Scope |
Despite all the advancements and technology, 5-10% of bone fractures are either nonunion or delayed. Treatment for critical size defects (CSDs) in bone often use bone grafts to act as a scaffold to help complete bony union healing. Biological scaffolds require bone extraction from the individual or an outside donor while synthetic grafts mostly suffer from poor degradation kinetics and decreased bioactivity. In this study, we propose a new bioink composed of alginate, collagen and doped with strontium-calcium polyphosphate (SCPP) to improve degradability and osteogenic/angiogenic properties of 3D printed scaffolds produced from this bioink. The characterization of the mechanical properties and degradation behavior of these scaffolds will be presented. We will also present results of cell-surface interactions via in vitro testing of these scaffolds for cell growth, proliferation and the mineralized tissue formation. The enhanced osteogenic effect of printing osteoblasts within these scaffolds will also be presented and discussed. |