|About this Abstract
||Materials Science & Technology 2020
||Next Generation Biomaterials
||Optimizing Bicontinuous Structure of Bijels-derived Polymer-hydrogel Hybrids for the Controlled Release of Different Cells
||Haoran Sun, Min Wang
|On-Site Speaker (Planned)
In tissue engineering, controlled cell release requires suitable vehicles for cells. Bijels-derived bicontinuous structures have interconnected channels which provide desired space for cell encapsulation, proliferation and migration. Our research develops new methods for fabricating bijels and bijels-derived structures with suitable channel (pore) sizes. In this investigation, bijels-derived polymer-hydrogel hybrids with normal pore size (~30 um) and large pore size (~60 um) were produced, and human dermal fibroblasts (HDFs) and osteoblast precursor cell line (MC3T3 cells) were encapsulated in the crosslinked alginate hydrogel in respective hybrid. The hybrids were then cultured to study cell release. It was observed that live cells were locked in hybrid structures and were gradually released during culture. Both HDFs and MC3T3 cells exhibited good cell viability and proliferation after their release and were able to migrate through channels to the surface of hybrids and then culture plates. The two types of cells displayed different release behaviors.
||Planned: Other (journal publication, etc.; describe below)