As has been well-established, life expectancy in many industrial nations is decreasing with many reasons such as a lack of personalized medicine, too much dependency on drugs to solve every health problem, lack of proactive (versus faulty reactionary medicine), and the list goes on. Moreover, there has been a lack of translation to real commercial products. This talk will summarize how nanotechnology with FDA approval can be used to increase tissue growth and decrease implant infection without using antibiotics. Studies will also be highlighted using nano sensors (while getting regulatory approval). Our group has shown that nanofeatures, nano-modifications, nanoparticles, and most importantly, nanosensors can reduce bacterial growth without using antibiotics. This talk will summarize techniques and efforts to create nanosensors for a wide range of medical and tissue engineering applications, particularly those that have received FDA approval and are currently being implanted in humans.