Transition-metal telluride nanocrystals offer a unique platform for realizing more sustainable materials for mid-infrared (mid-IR) and near-infrared (near-IR) laser and bioelectronic applications as compared to existing mercury-based compounds. To this end, a new class of binary and multinary telluride nanocrystals of tunable band gap and emissive properties are synthesized for the first time using a novel hot-injection approach. Multimodal material characterization using photoluminescence (PL), x-ray diffraction (XRD), scanning electron microscopy and energy dispersive x-ray spectroscopy, transmission electron microscopy is also explored with various multinary compositions synthesized (e.g., AuPtTe2, AuSbTe2, AuSnTe2, PtSnTe2, PtSbTe2, InPtTe2, InSbTe2, and InSnTe2) to understand the unique structure-property relationship of these new materials. It is discovered that defects play a major role in the PL of these nanocrystals and the Pt-Sn-based multinary telluride nanocrystals exhibit mid-IR emission. Results from this study will offer key insights on new quantum dots for biomedical devices and infrared lasers.