|About this Abstract
|2022 TMS Annual Meeting & Exhibition
|2022 Technical Division Student Poster Contest
|SPG-18: A Promising Orthopedic Implant Material with Enhanced Corrosion Resistance, Mechanical Properties, Osteogenic and Antibacterial Activity: Mg-Sc-Sr Alloy
|Nadia Aboutalebianaraki, Sudipta Seal, Mehdi Razavi
|On-Site Speaker (Planned)
Magnesium (Mg) alloys have gained interest in orthopedic applications due to their low density, biodegradability, and close mechanical properties to cortical bone. However, the rapid corrosion of Mg leads to high hydrogen gas evolution. We used scandium (Sc) and strontium (Sr) as alloying elements to construct an Mg-Sc-Sr ternary alloy to address this shortcoming. The effects of alloying elements and heat treatment on the microstructure, corrosion, mechanical properties, antimicrobial activity, and osteoconductivity of the Mg alloy were evaluated. The Mg-Sc-Sr showed a reduction in the corrosion rate, hydrogen evolution, and enhancement in the yield strength compared to Mg and also induced osteoblastic differentiation in vitro without showing toxicity. Additionally, microbiological counting, confocal microscopy, and scanning electron microscope (SEM) in vitro consistently demonstrated that Mg-Sc-Sr enhanced antibacterial activity compared to Mg. Based on our results, the Mg-Sc-Sr alloy is a promising candidate as a bone implant.
|Biomaterials, Magnesium, Other