| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
2022 Technical Division Student Poster Contest
|
| Presentation Title |
SPG-13: Engineering Ce3+ State in Cerium Oxide Nanoparticles Under The Presence of a Reducing Sugar |
| Author(s) |
Balaashwin Babu, Elayaraja Kolanthai, Craig Neal, Udit Kumar, Sudipta Seal |
| On-Site Speaker (Planned) |
Balaashwin Babu |
| Abstract Scope |
Ceria nanoparticles (CNP) are used in biological applications due to its ability to work as a reactive oxidative species (ROS) scavenger. Superoxide is a diatomic oxygen ROS which is responsible for the destruction of cells through oxidative damage. Superoxide dismutase (SOD) protein naturally scavenges O2- in biological systems but high levels require additional SOD-like catalysis. Most synthesized CNP contain high Ce4+ and acts a good catalase enzyme-mimetic. Some reported CNPs show high Ce3+ state but require a complex process. Herein, a simple wet-chemical synthesis utilizing glucose was engineered to create CNPs with high Ce3+ state. X-Ray photoelectron spectroscopy (XPS) show that the reducing potential of glucose allows for the enhanced Ce3+ state at physiological pH. The catalytic effect of synthesized CNP was tested using SOD and catalase assays. It was concluded that SOD activity was due to the enhanced Ce3+ activity while catalase activity was reduced. |
| Proceedings Inclusion? |
Undecided |
| Keywords |
Biomaterials, Nanotechnology, Other |