| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
|
| Presentation Title |
H-2: 3D Printable Bioscaffolds for Musculoskeletal Tissue Engineering using Ti_3 C_2 MXene Nanoparticles to Enhance Conductivity and Improve Cell Viability |
| Author(s) |
Annaka Tibbits, Miranda L Nelson, Hailey M Burgoyne, Fereshteh Rajabi Kouchi, Raquel Montenegro-Brown, David Estrada |
| On-Site Speaker (Planned) |
Annaka Tibbits |
| Abstract Scope |
Musculoskeletal disease is the number one cause of physical disability in the world. A potential cure for this is tissue engineering; specifically, culturing STEM cells into scaffolds to create tissue specific grafts to be surgically implanted. We successfully printed bioscaffolds with high structural integrity and sufficient conductivity to aid in the functionality of the muscle cells by using cell-laden bioinks with Ti3 C2 MXene nanoparticles. Furthermore, we tested GelMA, GelXA, and Cellink bioinks at a seeding density of 1∙106 cells/mL with 0, 0.1, and 1.0 mg/mL MXene concentrations. UV Crosslinking of GelMA and GelXA was determined to be less functional with higher concentrations of MXenes due to light deflection. Additionally, chemical crosslinking in GelXA and Cellink led to better structural integrity. Overall, MXenes improved the mechanical and electrical properties of the scaffolds while maintaining cell viability. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Additive Manufacturing, Biomaterials, |