Abstract Scope |
It is important to improve the blood coagulation responses of biomaterials used in cardiovascular devices. Polyurethanes has been widely used in implantable cardiovascular medical devices due to their biocompatibility and excellent mechanical properties. In this study, we characterized the surface properties of four polyurethane biomaterials: MS 0.4, BioSpan S, BioSpan 2F, and CarboSil 20 80A, including surface chemistry, topography, phase structure and wettability. We also studied the ovine, bovine, and human blood plasma coagulation responses to these materials in vitro, as well as the FXII contact activation. Results showed that BioSpan 2F contains high amount of F while other materials consist mostly of Si. An in vitro coagulation assay and a chromogenic assay were performed to show FXII contact activation. These materials demonstrated improved blood coagulation responses compared to the control, there was no significant difference in the coagulation time and the activated FXII yield among the polymers. |