| About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Student Poster Contest + Rapid Fire
|
| Presentation Title |
C-21: Villi Inspired Elastomeric Interlocking Device for Intestinal Retentive Applications |
| Author(s) |
Durva Naik |
| On-Site Speaker (Planned) |
Durva Naik |
| Abstract Scope |
Achieving prolonged retention of medical devices in the small intestine remains a significant clinical challenge. Here, we investigate mechanical interlocking between high-aspect-ratio elastomeric microposts and villi to develop intestinal retentive platforms. Preliminary assessment of this strategy is done via FEA based mechanical simulations. Interlocking efficiency of microposts is characterized as a function of their moduli and extent of overlap between the micropost and villus. Further, we analyze interlocking between devices laminated with microposts and villi to evaluate their efficacy to resist peristaltic stresses by varying the design and material properties. Simulations are then validated by performing lap-shear tests between artificial villi and devices fabricated by DLP 3D printing in tandem with a multi-step replica molding technique. We demonstrate that these devices effortlessly consolidate within the villi under contractile pressure and resist peristaltic shear via mechanical interlocking. This study presents a novel, compliant and non-penetrative strategy to develop intestinal retentive platforms. |