New bio-inspiration, micro-/nanomaterials, physics, and micro-/nanomanufacturing processes offer unprecedented opportunities in engineering surfaces for novel photon management strategies, difficult-to-realize material–property combinations, and new multi-functionality. In this talk, we discuss some of my research group’s recent progress in the creation of multi-functional surfaces. We discuss optical properties such as broadband and broad angle antireflection as well as haze. In addition we discuss functionalities such as self-cleaning, stain-resistance, anti-fogging, and anti-biofouling. Finally, we discuss major challenges with the issue of mechanical durability in these surfaces and potential strategies for addressing these issues. These surfaces may have a wide range of applications including optoelectronic devices, medical textiles, and healthcare surfaces.