| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
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| Symposium
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Bio-Nano Interfaces and Engineering Applications
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| Presentation Title |
Continuous Flow Process of Surface-engineered, pH-responsive CeO2 Nanozymes With Tumour-killing Potency
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| Author(s) |
Sayoni Sarkar, Ajit Kulkarni |
| On-Site Speaker (Planned) |
Sayoni Sarkar |
| Abstract Scope |
Surface functionalized, oxygen vacancy (VO)-rich CeO2 nanostructures were fabricated utilizing an in-house designed continuous flow process, governed by the Lamer-mechanism mediated nucleation and growth to aid in suitable lab-to-field translation. The altered surface chemistry due to the presence of abundant VO was assessed by XPS, Raman, and EPR spectroscopy. The concentration of Ce3+, Ce4+ and surface VO determined through XPS spectral changes were estimated to be 51.6%, 48.4%, and 29%, respectively. The strained crystal lattice due to the presence of higher Ce3+ was observed in the Raman spectra (peak broadening and shift). Moreover, structure-property correlation revealed the appreciable pH-responsive peroxidase (more potent than natural horse radish peroxidase) and catalase enzyme-mimicking efficacy due to the higher Ce3+/Ce4+ helped in combating oxidative stress-related toxicity tested on HeLa (cancerous) cells. Thus, this low-cost, engineered-nanozyme harbours transformative potency for hitherto unreported, advanced, cancer mitigation through transferrin-mediated endocytosis and pH-responsive combinatorial therapeutic strategies. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Nanotechnology, Biomaterials, Process Technology |