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Meeting 2024 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title The Difference of Trabecular and Cortical Bone Material Properties at the Proximal Hip May Influence Bone Fragility
Author(s) Philipp Thurner, Martin Frank, Andreas Reisinger, Katja Haslinger, Dieter Pahr
On-Site Speaker (Planned) Philipp Thurner
Abstract Scope The diagnosis of osteoporosis in patients prior to a fragility fracture remains a challenge. Here, bone material properties might improve diagnostic prediction. Here, the putative change of bone properties with age and disease is of interest. Conducting mechanical tests at the meso- and micro scale and comparing trabecular and proximal bone from osteoporotic and healthy donors, diseased bone was not different to healthy bone. Additionally, trabecular and cortical bone tissue are often thought to display similar linear elastic behavior and properties at the tissue level. However, our experiments on trabecular and cortical bone from the same human donors show, that these are in fact two distinct tissues. At low strains cortical bone displays linear elastic behavior while trabecular bone is viscoelastic. As the femoral neck cortex undergoes trabecularization with age, this may have a significant effect on bone fragility, yet clinical relevance of this remains to be shown.
Proceedings Inclusion? Planned:
Keywords Biomaterials, Mechanical Properties, Other

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Exploring the 3-Dimensional Structure and Composition of Dental Enamel at the Nanoscale
H-10: Cooperative Surface Self-assembly Kinetics of Metal Binding Peptides by Spectral Rate Distribution
H-11: Low-cost Customizable 3D Printed Biohybrid Scaffolds
H-12: Machine Learning-guided Identification of Antimicrobial Peptides Targeting Oral Health
H-13: Multi-functional Peptide-polymer Hybrids for Dental Tissue Repair
H-14: siRNA and Cerium Oxide Delivery With Ultrasound-sensitive Nanobubbles for Bone Disease Treatment
H-15: The Nanoscale Interface and Structure Function Properties of Cortical Bone
H-7: Broad Spectrum, Potent and Durable Ceria Nanoparticles Inactivate RNA Virus Infectivity by Targeting Virion Surfaces and Disrupting Virus-receptor Interactions
H-8: Carbon Negative Deeply Structured Hierarchical Ceramics Derived From Biogenic Silica
H-9: Collagen Platform Exploring Antimicrobial Peptide-polymer Hybrids
Inkjet-printed Nanopatterned Aptasensors for Lateral Flow Detection of Foodborne Pathogens
Interpenetrating Polymer Network as Interface Material in Bioinspired Composites
Matrix Assisted Pulsed Laser Evaporation for Layer-by-Layer Processing of Thin Films for Biomedical Applications
Measuring and Calibrating Interfacial Forces at Hard and Soft Interfaces via Force Spectroscopy for Quantitative Materials Description
Mechanically and Biologically Tunable Biomaterials
Molecular Insights Into Mineral Nanoparticle Interactions With Proteins
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Quantifying Surface Topographies on Antimicrobial Copper
Rapid Prototyping of Additively Manufactured Cell Culture Chambers With Integrated Nano-biosensors
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The Difference of Trabecular and Cortical Bone Material Properties at the Proximal Hip May Influence Bone Fragility
Towards Effective Therapies for Bone Metastasis of Breast Cancer Using Novel Phenolic Compounds

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