Harvesting the new capabilities introduced by additive manufacturing (AM) technology, Siemens Energy has been improving the functionalities of the engine parts and improving design process agility by reducing iterations lead time. However, the unique microstructure/texture of the additively manufactured products results in mechanical properties that are anisotropic. Consequently, predicting the mechanical properties and functional performance (e.g., life assessment) of selective laser melting (SLM) components through finite element simulations become crucial. In this study, the anisotropic plasticity behavior of a nickel-based superalloy, manufactured by SLM, is characterized and modeled. Uniaxial tensile and low cycle fatigue (LCF) tests were carried out for samples printed in three orientations with respect to growth direction (i.e., 0, 45, and 90 degree) at a various temperatures ranging from 25 to 700 °C. A quadratic anisotropic yield function, Hill’s 48 in addition to three different hardening laws, i.e. isotropic hardening, combined kinematic and isotropic (Chaboche), and multilinear kinematic (Mroz) models, were considered in this study. The models’ parameters were assessed. The models were implemented in finite element simulations using ABAQUS. Finally, the performance of each model was analyzed and validated by comparing finite element predictions to experimental observations.