|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||2022 Technical Division Student Poster Contest
||SPG-13: Engineering Ce3+ State in Cerium Oxide Nanoparticles Under The Presence of a Reducing Sugar
||Balaashwin Babu, Elayaraja Kolanthai, Craig Neal, Udit Kumar, Sudipta Seal
|On-Site Speaker (Planned)
Ceria nanoparticles (CNP) are used in biological applications due to its ability to work as a reactive oxidative species (ROS) scavenger. Superoxide is a diatomic oxygen ROS which is responsible for the destruction of cells through oxidative damage. Superoxide dismutase (SOD) protein naturally scavenges O2- in biological systems but high levels require additional SOD-like catalysis. Most synthesized CNP contain high Ce4+ and acts a good catalase enzyme-mimetic. Some reported CNPs show high Ce3+ state but require a complex process. Herein, a simple wet-chemical synthesis utilizing glucose was engineered to create CNPs with high Ce3+ state. X-Ray photoelectron spectroscopy (XPS) show that the reducing potential of glucose allows for the enhanced Ce3+ state at physiological pH. The catalytic effect of synthesized CNP was tested using SOD and catalase assays. It was concluded that SOD activity was due to the enhanced Ce3+ activity while catalase activity was reduced.
||Biomaterials, Nanotechnology, Other