| Abstract Scope |
With the increase in the world’s elderly population, the number of orthopedic implant surgeries is increasing. Patients undergoing these surgeries commonly suffer post-implantation infection due to the invasion of infectious agents. Antibiotics have been in use to treat these infections. However, their high doses, multidrug resistance, and toxicity concerns have prompted the need for alternative, safer options. In this work, we have developed a novel approach using curcumin and epigallocatechin gallate, the bioactive compounds from turmeric and green tea, known for excellent antibacterial and bone-forming ability. We aim to fabricate calcium phosphate-coated titanium, loaded with both drugs, to heal bone defects while preventing infection. The controlled release of combined drugs showed antibacterial efficacy by 94 % and enhanced osteoblast viability by 3-fold compared to control, indicating bone growth. The results indicate that these multifunctional implants loaded with natural compounds could be a promising strategy for infection prevention and bone tissue engineering. |