| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
Controlled Synthesis, Processing, and Applications of Structural and Functional Nanomaterials
|
| Presentation Title |
The Role of Collagen Piezoelectricity in the Intrafibrillar Mineralization |
| Author(s) |
Jinha Kwon, Hanna Cho |
| On-Site Speaker (Planned) |
Hanna Cho |
| Abstract Scope |
Bone adapts to external loads by modulating its mechanical properties through mineralization. During intrafibrillar mineralization, net-charged amorphous calcium phosphate (ACP) mineral precursors infiltrate the collagen fibril's intrafibrillar space through gap regions. However, the underlying driving force behind this process remains unclear. We hypothesized that collagen's piezoelectricity locally increases electrical interaction to help ACP infiltrate small gap regions. We used advanced piezoresponse force microscopy (PFM) to compare the piezoelectricity of collagen fibrils extracted from wild type (WT) and osteogenesis imperfecta (OI) bone, which exhibits abnormal mineralization due to a genetic collagen mutation. The result identified anisotropic and heterogeneous piezoelectric properties correlated with collagen structure in WT bone. However, OI collagen had relatively homogenous piezoelectricity, losing piezoelectric periodicity along the fibril. Our findings suggest that collagen's piezoelectric heterogeneity is an essential mechanism for locally modulating the electric interaction and promoting ACP infiltration into gap zones for intrafibrillar mineralization. |