|About this Abstract
|Materials Science & Technology 2020
|Next Generation Biomaterials
|Novel Hierarchical Carbon Nantotube-coated Materials as Bioscaffolds for Keratinocyte Cell Growth
|Soham Parikh, Courtney Sulentic, Sharmila Mukhopadhyay
|On-Site Speaker (Planned)
Injuries involving skin cause a huge social and financial burden. In 2018, skin related injuries required more than $28 billion for Medicare. Carbon nanotubes (CNTs) have been successfully used for cell scaffolding and are effective in adhesion, growth, and differentiation of various cells; however, they have not been investigated in detail for aiding keratinocyte growth. The proposed project aims to determine the use of covalently bonded CNT-coated hierarchical carbon scaffolds made in our lab for sustaining keratinocytes for future development of novel skin autografts. In this study, we found that CNT-coated scaffolds could support cell growth and could maintain normal proliferation while healing progresses. We have found that keratinocyte cell growth can be modified through wettability control and CNT-coated scaffolds promote cell proliferation of keratinocytes and are not cytotoxic. While detailed cell growth analyses are underway, preliminary results strongly support future potential of our bio-mimetic scaffolds in tissue engineering.