|About this Abstract
|Materials Science & Technology 2020
|Next Generation Biomaterials
|3D Printed Porous Tissue Engineering Scaffolds with the Self-folding Ability and Controlled Release of Growth Factor
|Jiahui Lai, Junzhi Li, Min Wang
|On-Site Speaker (Planned)
3D printing technologies enable the fabrication of porous scaffolds with good control over their architectures and properties. 3D printed scaffolds with shape morphing ability can reshape themselves after implantation to match the defect and anatomy of host tissues. Growth factors are often used in tissue engineering to accelerate tissue regeneration, and vascular endothelial growth factors (VEGF) enhances the regeneration of gastrointestinal tract and vasculature. In this study, an extrusion-based 3D printing system was used to construct porous scaffolds which have abilities of self-folding upon heating to the human body temperature and controlled release of VEGF. For 3D printed scaffolds, the self-folding ability was achieved by using poly(D, L-lactide-co-trimethylene carbonate) (PDLLA-TMC) which could change shape at a temperature greater than 37°C, while the controlled release of growth factor was achieved by using gelatin methacrylate (GelMA) as the functional layer to load VEGF. Different techniques were used to evaluate the printed scaffolds.