|About this Abstract
|Materials Science & Technology 2020
|Next Generation Biomaterials
|Decellularized Lucky Bamboo (Dracaena sanderiana) Scaffolds for Bone Tissue Engineering
|Ali Salifu, Joshua Gershlak, John Obayemi, Vanessa Uzonwanne, Glenn Gaudette, Winston Soboyejo
|On-Site Speaker (Planned)
Many of the proposed alternative strategies for the repair of non-union bone defects rely on the development of synthetic scaffolds for bone regeneration that are limited by their structure and scale-up capabilities. With its well-organized, hierarchical and functionally graded structure, and its potential for large scale cultivation, lucky bamboo is presented as a cost-effective, scalable alternative for scaffold development. Hence, we developed decellularized lucky bamboo scaffolds functionalized with arginine-glycine-aspartate (RGD) peptides and characterized their physicochemical properties. The attachment, proliferation, and organization of human fetal osteoblast (hFOB) cells, and extracellular matrix (ECM) production and mineralization were demonstrated. The mechanical properties of the cell-laden decellularized scaffolds were also studied at different times and were shown to evolve at different stages of cell proliferation, ECM production, and mineralization. The data suggest that decellularized lucky bamboo scaffolds may provide biological material for use in bone repair in an environmentally and economically sustainable way.