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Meeting 2026 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title Spider Silk Nanofibrils: From Building Blocks of Natural High-Performance Fibers to Applications in Synthetic Materials
Author(s) Hannes C. Schniepp, Jacob Silliman
On-Site Speaker (Planned) Hannes C. Schniepp
Abstract Scope Spider silk is a multifunctional material featuring outstanding mechanical properties, biocompatibility and sustainability. Consisting 100% of protein, it is a versatile 21th-century material. We have shown that many important silks are entirely made from uniform nanofibrils, about 10-20 nm in diameter. This suggests that the traits of spider silks are already present in individual nanofibrils, making them important to study. We have studied their mechanical and adhesive properties, and their protein secondary structure. We have carried out mechanical tensile tests of individual spider silk nanofibrils for the first time, showing that they are extremely stretchable, by 1,000%. We have also decomposed silk fibers entirely into their nanofibrils, which we have re-assembled into materials with different geometries. Characterization of these materials does not only present new application opportunities, but also offers deeper insights into the properties of spider silk nanofibrils themselves.
Proceedings Inclusion? Planned:
Keywords Characterization, Sustainability, Mechanical Properties

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

Adaptive mechanisms and mineral interactions of microbes in extreme environments
Bilayer silk protein paper
Biomolecular Recognition at Microplastic-Sperm Cell Interfaces: Elucidating Structure-Function Relationships in Environmental Reproductive Toxicology
Designing Antibacterial Properties of Alloys
Dopant distribution and structural response in europium-doped hydroxyapatite: The role of charge compensation from a first-principles perspective
Engineering a Capillary-Mimetic Hydrogel Barrier for a Bone-on-a-Chip Microfluidic Model of Diabetic Skeletal Degeneration
Hierarchical elastoplasticity of cortical bone: Observations, mathematical modeling, validation
Immobilization of laccases on CuO and ZnO nanoparticles: Stability, catalysis and water bioremediation
In silico evaluation of materials for eliciting cellular responses
Macroscale Superlubricity Coatings for Metallic Alloys
Metastasis testbeds: the future of personalized medicine
Micro-Nano Biomimetic Surface Design of 3D Printed PEEK Implants
Multinuclear Solid-State NMR Reveals Calcium Environments and Surface Reactivity in Morphologically Distinct Hydroxyapatite Nanoparticles
Multiscale Toughening Architectures in Desert Beetle Armor
Nano-scale Chemical Variations revealed by Secondary Electron Hyperspectral Imaging and X-Ray Ptycho-tomography
Nanostructured Materials for Transdermal Sensing
Phase Transformation of Amorphous Calcium Carbonate: Effects of Crystalline Substrates and Solution Chemistry
Phononic Landscape of Natural Biomaterials – Lessons for Bioinspiration
Quantifying Bacterial Interactions at Bio-Nano Interfaces to Engineer Mechanobactericidal Surfaces
Reversible Esterfication of Horseradish Peroxidase with Poly(aminophenylboronic acid) Nanorods Coated on Flexible Polypropylene Membranes
Scalable Hierarchical Surface Restructuring for High-Performance Neural Interfacing Electrodes: Electrochemical, Antibacterial, and Manufacturing Perspectives
Spider Silk Nanofibrils: From Building Blocks of Natural High-Performance Fibers to Applications in Synthetic Materials
Structural Characterization and Mechanical Design Strategies of Land Snail Shells
Synthesis and Conjugation of non-toxic quantum dots to porphyrins as novel theranostic agents against bacterial and cancerous cells
Synthesis of ternary quantum dots for instant degradation of organic dye in contaminated water and its conjugation to porphyrin for improved phototherapy application.
Textural and Nanomechanical Analysis of Polycrystalline Biogenic Aragonite in Coral Skeletons
Theragnostic nanobiomaterial for liver fibrosis using upconversion nanoparticles and carbon dots
Tunable, light-actuated silk fibroin composites for sensing and actuation at biointerfaces

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