About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Metastasis testbeds: the future of personalized medicine |
| Author(s) |
Kalpana S. Katti, Dinesh Katti, Quyen Hoang, shrinwanti Ghosh, Jiha Kim |
| On-Site Speaker (Planned) |
Kalpana S. Katti |
| Abstract Scope |
While tissue-engineering along with 3D printing are a promising future of regenerative medicine, a new application of tissue engineering is development of realistic humanoid testbeds of diseases such as cancer. Breast and prostate cancer alone result in over 1M deaths worldwide each year. The most predominant site of metastasis for these cancers is bone. We have developed tissue-engineered bone-mimetic scaffolds seeded with human-mesenchymal cells to develop bone-mimetic structures further seeded with patient-derived breast cancer and prostate cancer cell lines. In addition, soft tissue co-cultures with breast cancer and prostate cancer are also developed. The use of a specially designed horizontal-flow bioreactor enables the flow of cells from the soft-tissue-primary site of cancer to the bone-metastatic site at physiologically relevant flow. We use this testbed to evaluate efficacy of drugs and phytochemical enhanced specialty crop extracts. Overall. this testbed approach presents a safe, efficacious and cost effective route for personalized medicine. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Composites, Ceramics |