About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Synthesis and Conjugation of non-toxic quantum dots to porphyrins as novel theranostic agents against bacterial and cancerous cells |
| Author(s) |
Samuel Oluwatobi Oluwafemi |
| On-Site Speaker (Planned) |
Samuel Oluwatobi Oluwafemi |
| Abstract Scope |
Photodynamic therapy (PDT) is a non-invasive treatment modality that uses photosensitising drugs (PS) to generate reactive oxygen species (ROS) for the destruction of abnormally growing cells or microorganisms. Among these PS, porphyrins are the most widely used in PDT; however, their clinical application is limited by poor water solubility, which often results in aggregation and low quantum yield of ROS generation after light absorption in the near-infrared region (NIR). To overcome these limitations and improve PDT efficacy, we herein report the conjugation of different ternary QDs to both neutral and cationic porphyrins, followed by the cell viability, photothermal and PDT efficacy of the resultant novel conjugate against cancerous cells and nosocomial bacteria. The results of this study show that the as-synthesised conjugates a suitable and promising class of material for imaging, anti-cancer and antimicrobial PDT. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Nanotechnology, Other, Other |