| Abstract Scope |
Lanthanides are widely recognized for their applications in catalysis, high-temperature coatings, optical displays, and glass polishing. Most recently, we have explored the therapeutic potential of one lanthanide, nanoceria (CNP), due to its radical-scavenging properties analogous to antioxidants. Building on this unique redox property, we examined the capability of surface-engineered CNPs to mitigate cellular damage under high-intensity radiation. Notably, our optimized CNP preparation demonstrated selective cytoprotection, shielding healthy cells while efficiently targeting and eliminating cancer cells in a breast cancer model, depending on radiation dosage. In another study, we have looked into Musculoskeletal atrophy, which has serious implications for astronaut health for planned Moon and Mars mission. Examples will include the role non-toxic CNPs with high fraction of trivalent (Ce3+) surface sites, are shown to neutralize ROS and mitigate radiation- and unloading-induced damage to bone architecture and strength in vivo. Furthermore, a combinatorial approach using CNPs with P7C3 produced synergistic effects, rescuing cells when administered as a radiomitigative strategy. Ultimately, our goal is to develop an effective therapeutic radio-countermeasure that safeguards astronaut health during deep-space missions while also supporting bone health applications on Earth. |