About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Theragnostic nanobiomaterial for liver fibrosis using upconversion nanoparticles and carbon dots |
| Author(s) |
Gabriela I. Carballo-López, Prakhar Sengar, Gustavo A. Hirata-Flores, Ana B. Castro-Ceseña |
| On-Site Speaker (Planned) |
Gabriela I. Carballo-López |
| Abstract Scope |
We developed a theragnostic nanobiomaterial based on NaYF₄:Yb³⁺,Er³⁺ upconversion nanoparticles (UCNPs), coated with silica to allow surface functionalization. Carbon dots (CDs) derived from Aloe vera and Moringa oleifera were conjugated via a photosensitive nitrobenzyl linker, enabling light-triggered antioxidant release. Simultaneously, anti-COL1A1 antibodies were covalently attached through amide bonding to target fibrotic sites. The UCNPs provide NIR-triggered photoluminescence for imaging, while the CDs act as therapeutic antioxidants. The nanobiomaterial was synthesized, characterized, and evaluated in a 3D hepatic spheroid model comprising hepatocytes, stellate cells, and Kupffer cells, mimicking Metabolic Associated Steatohepatitis (MASH) conditions. Preliminary results support efficient targeting and luminescence-based localization in fibrotic zones, demonstrating potential for targeted therapy and diagnosis. This multifunctional system offers a promising approach for noninvasive monitoring and selective treatment of fibrosis in MASH. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Nanotechnology, Biomaterials, Other |