| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
|
| Presentation Title |
Mineral Ellipsoids and Nanochannel Structures in Bone |
| Author(s) |
Tengteng (Toni) Tang, Alyssa Williams, Chiara Micheletti, Mike Phaneuf, Nabil Bassim, Aurelien Gourrier, Kathryn Grandfield |
| On-Site Speaker (Planned) |
Tengteng (Toni) Tang |
| Abstract Scope |
The mechanical competence of bone is attributable to its organic and inorganic constituents and their three-dimensional (3D) organization at each length scale. Recent advances in (plasma) focused ion beam-scanning electron microscopy have allowed the investigation of bone architecture in 3D at the meso- and nanoscale and provide new insight into the structure-function relationships in bone. Here, we demonstrate and discuss the recently discovered mineral ellipsoids and nanochannels in bone and their potential role in mineralization. The omnipresent mineral ellipsoids have a distinct packing pattern across the layers of bone lamellae and their orientation and shape are closely related to the collagen fibrils organization. These mineral ellipsoids also seem to be associated with and surrounded by an extensive network of nanochannels which are ten times smaller than the bone canaliculi. These nanochannels could potentially provide ion and molecule access to the mineral ellipsoids and facilitate their growth and mineralization. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Other, |