| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
|
| Presentation Title |
Bone Adaptation as a Response to Mechanical Loading in Zebrafish |
| Author(s) |
Bjorn Busse |
| On-Site Speaker (Planned) |
Bjorn Busse |
| Abstract Scope |
Musculoskeletal exercise promotes bone maintenance through adaptive responses of the skeleton. This mechanism has the potential to counteract age- and disease-related bone loss. To study the effects of exercise on bone quality, zebrafish emerged as a promising vertebrate model. Bone adaptation processes in adult zebrafish have been characterized after the animals were subjected to increased physical exercise in a swim tunnel experiment. Cellular, structural and compositional changes of the loaded skeleton were quantified using high-resolution imaging and microanalyses. Exercise induced rapid bone adaptation with increases in bone-forming osteoblasts, bone volume fraction and mineralization. Modeling processes in zebrafish bone resemble processes in human bone. The study highlights how exercise experiments in adult zebrafish can contribute to affect aging-related bone diseases and can thus help to maintain bone quantity and quality. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Mechanical Properties |