A high-throughput synthesis method is developed to study the high entropy alloys (HEAs) based on the powder metallurgy sintering approach. A structural container with a honeycomb array of internal housing is firstly made by additive manufacturing, then filled with powder mixture via combinatorial design, degassed and sealed, consolidated by hot-isostatic-pressing (HIP) process, followed with high temperature heat treatment, and finally formed more than 80 bulk HEAs with various chemistry. These combinatorial HEAs contain 13 elements, including Fe, Cr, Co, Ni, Mo, Mn, W, Si, Nb, Ti, Ta, Cu, and Al. There are 18 types of material system among these HEAs. They are characterized by different high-throughput analyzing methods, such as LIBS, micro-XRF, Full-View-Metallography, SEM, micro-XRD and Scanning-Micro-Hardness etc. The effects of chemistry on microstructure and property are studied. This work put forth a new high-throughput HIP micro-synthesis approach for accelerating the design and screening of bulk HEAs and other materials.