In this presentation, I will briefly highlight the research activities on bulk-metallic glasses (BMG), high-entropy alloys (HEAs), and other structural materials by our group members and collaborators. I am most grateful that many wonderful students and friends have greatly and graciously help and formulate our research activities. It is truly a great pleasure for me to learn from and interact with our students and friends on research, papers and proposal writings. The talk will focus on microstructures and mechanical behavior of BMGs and HEAs, in particular, fatigue and fracture behavior. In-situ neutron and synchrotron diffractions have been used to understand the phase transformation and mechanical behavior. Moreover, theoretical models have been developed to quantify and predict the phase evolution and mechanical performance. We are very grateful for the financial support from the National Science Foundation, Department of Energy, Army Research Office, Industries, Westinghouse, University of Tennessee, etc.