| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
An Insight into Cellular Protein Mechanics during Cancer Progression |
| Author(s) |
Dinesh Katti, Sharad V Jaswandkar, Hanmant Gaikwad, Kalpana S. Katti |
| On-Site Speaker (Planned) |
Dinesh Katti |
| Abstract Scope |
The evolution of mechanobiology of cancer cells during cancer progression is associated with the dynamics of several cellular proteins. The cellular proteins actin and integrin play a critical role during cancer progression. The dynamic remodeling of an actin cytoskeleton is observed in cellular processes such as tumor cell transformation and metastasis. The adhesion protein integrin is essential in adhering cancer cells to the extracellular matrix and mechanotransduction. Here, we present the mechanics of these two crucial proteins using steered molecular dynamics simulations and their potential roles in the mechanobiology of breast and prostate cancers during progression at the bone metastasis site. Our simulations unravel the fundamental mechanisms that play a vital role in cancer cell cytoskeletal and adhesion dynamics during cancer progression at the bone metastasis site. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Computational Materials Science & Engineering, Modeling and Simulation |