| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Multi-functional Peptide-mediated Intrafibrillar Remineralization for Dental Tissue Repair |
| Author(s) |
Aya Kirahm Cloyd, Kye Boone, Qiang Ye, Paulette Spencer, Candan Tamerler |
| On-Site Speaker (Planned) |
Aya Kirahm Cloyd |
| Abstract Scope |
Dental caries are the most prevalent chronic disease globally, affecting nearly 3.9 billion people. One-third of the world’s population suffers from untreated caries and underserved populations are disproportionally affected. To date, resin composites used for dental tissue restoration show poor longevity and require subsequent clinical interventions due to critical failure in the dental adhesive. Poor adhesive infiltration of demineralized collagen leaves collagen fibers exposed and the adhesive-dentin hybrid layer open to bacterial degradation and further demineralization. Our approach investigates a multi-functional peptide-mediated intrafibrillar remineralization approach to strengthen this vulnerable site. We engineered a bifunctional peptide that binds to collagen and mediates enhanced localized remineralization. We will share our promising experimental results to repair this complex interface using combined spectroscopic and microscopic characterization including AFM, and SEM-EDX. Our studies provide a critical step toward developing a next generation peptide-enabled dental adhesive that effectively repairs caries-affected dentin. |
| Proceedings Inclusion? |
Planned: |