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Meeting 2023 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title Influence of Nanoscale Hydration on the Micro-structural Properties of Human Cortical Bone
Author(s) Elizabeth Montagnino, Glynn Gallaway, Thomas Siegmund , John Howarter
On-Site Speaker (Planned) Elizabeth Montagnino
Abstract Scope Hydration at the nanostructural level of bone, a hierarchal composite material, has an essential role in fracture resistance. Bound water found within the collagen triple-helix increases the volume of the organic matrix while, water at the collagen-mineral interface transfers load between the phases, both having an influence of the overall fracture toughness. Small-angle x-ray and wide-angle x-ray scattering (SAXS/WAXS) was used to characterize D-spacing under tensile load for bone specimen with controlled degrees of internal hydration. To modulate the water in the organic matrix and at the collagen-mineral interface, human cortical bone samples were partially dehydrated and demineralized in controlled environments and then treated under pharmaceutical conditions to understand the ability of the organic matrix to hydrate and improve the mechanical response of the bone. This work is supported by NSF Award 1952993
Proceedings Inclusion? Planned:
Keywords Biomaterials, Mechanical Properties, Characterization

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From Molecular Interactions to Macroscopic Properties: Studying Protein-based Structural Materials Across the Scales
Hierarchical Surface Restructuring for Next Generation Implantable Neural Interfacing Applications
Influence of Fluid Flow on Inducing Bone Metastasis through use of a Novel Bioreactor with In Vitro Cancer Models
Influence of Nanoscale Hydration on the Micro-structural Properties of Human Cortical Bone
Multi-functional Peptide-mediated Intrafibrillar Remineralization for Dental Tissue Repair
Nanostructural Bone Remodeling at the Interface to Mg Implants
Self-assembled Flavoprotein Putrescine Oxidase System Offers Enhanced Thermal Stability
Sisal-inspired Multilevel Structure for Fog Collection Fabricated by Additive Manufacturing and Surface Modification

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