Heat assistant approach is promising to promote the formability of hard-to-form materials such as titanium alloy sheets. However, under thermal-mechanical coupling effects, the non-uniform deformation related anisotropic plasticity, damage and fracture of the material may be complicated and urgently need to be fully understood and accurately described. Thus, the experiments along different loading directions under various temperatures are conducted, and a yield-fracture locus in the stress plane is attempted to be plotted, revealing the distinct anisotropic yield and fracture evolution of the alloy during various thermal-mechanical loading conditions. Then, considering the effects of temperature on anisotropy plasticity and damage, a heat related discontinuous plasticity-fracture model is established and numerically implemented into FE simulation to smoothly present the evolution of plasticity and fracture behaviors. The comparison between the experimental results and numerical ones verifies the proposed model for describing the anisotropy in plasticity and ductile fracture under various thermal-mechanical loading conditions.