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Meeting 2024 TMS Annual Meeting & Exhibition
Symposium Advanced Biomaterials for Biomedical Implants
Presentation Title The Development of Antimicrobial Ti-Cu Alloys and Understanding of their Mode of Action
Author(s) Daisy Rabbitt, Luke N Carter, Victor Villapun, Sophie Cox, Alexander Knowles
On-Site Speaker (Planned) Daisy Rabbitt
Abstract Scope Innovation of metallic materials for biomedical implants is stagnant in comparison to other industries, with titanium alloys being dominant, due to excellent mechanical properties and biocompatibility. Nevertheless, there are a number of unaddressed challenges facing orthopaedic implants, in particular infection. Colonisation of device surfaces with bacteria may lead to implant revision or severe consequences to the patient’s quality of life. Herein we aim to design an inherently antimicrobial alloy that prevents or limits bacterial growth and colonisation. Titanium-copper alloys have been researched as a method to kill bacteria; however, the mechanism of action has still been widely debated. Consequently, different Ti-Cu compositions have been evaluated. Varying manufacturing methods and heat treatments have been used to produce different microstructures and phases to fully explore these compositions. Characterisation techniques have been used to determine how the composition, phases, and microstructure all work together to help establish their efficacy and mode of action.
Proceedings Inclusion? Planned:
Keywords Biomaterials, Titanium, Copper / Nickel / Cobalt

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

Bioactive Glasses for Bone Repair and Dental Applications: A Review of Osteointegration and Controlled Ion Release Capabilities
Biocompatibility Evaluation of TiZrNbSiMo High Entropy Alloy Coatings Fabricated by High Power Impulse Magnetron Sputtering
Bioinspired and Electrospun Helically Structured Nanofibers for Cardiac Patch Application
Bone Reconstruction Patient-specific Implants Based on PEI
Corrosion Behaviour of Ti-xCu Alloys for Dental Applications
Design-specific and Multi-functional (Bioactive and Antibacterial) PEEK-based Implants
Design and Application of Porous PDMS Membrane Devices in Nude Mice for Localized Treatment of Triple Negative Breast Cancer
Design and Enhancing Bbiocompatibility of β- titanium Alloy via Electro-discharge Treatment Process
Development of Antibacterial Metal Oxide Thin Films for Neurostimulation Applications via Atomic Layer Deposition
Development of Antibacterial Neural Interfacing Electrodes via Hierarchical Surface Restructuring and Atomic Layer Deposition
Enhancing Mechanical Properties of a Lightweight Biomimetic Structure by 3D Printing for Bone Tissue Engineering Application
Exploring the Microstructure of Marine Sponge Spicules: Insights for Biomimetic Bone Tissue Engineering
H-1: Bioactive Glass-ceramic Nanoparticle for Medical Implants
Hybrid Manufacturing of Superelastic Arterial Stents
Improving Free Flap Donor Site Stabilization with the Use of Additively Manufactured Custom Fixation Plates
Improvisation of Phase Stability and Texture in Biomedical Ti-based Alloys for Ultra Low Modulus Applications
In Vivo InflammatoryReaction and Elemental Trafficking of Magnesium Bioimplant Derived Aluminum
Manipulating Precipitate Population to Modulate Corrosion and Al Release in Mg-9Al Biodegradable Implants
Mechanical Integrity Testing of Bioresorbable Zn-based Alloy Under Static and Cyclic Loadings
Microstructural and Mechanical Analysis of Aerosol Jet 3D Printed Micropillars and Their Biocompatibility in Mouse Brain
Nano-biosensor to Manage COVID-19 Infection and Long-COVID
New MRI-compatible Metallic Materials for Miniaturized Implants
Novel Ti-10Mo-Mn Alloys for Biomedical Applications
Optimizing Printing Orientation for Spicule-Inspired Structures for Biomedical Applications
Optimizing the Bio-degradability and Biocompatibility of a Biogenic Collagen Membrane Through Cross-linking And Zinc-doped Hydroxyapatite
Orthopedic Patient Specific 3D Printed Implants Based on Novel Composite PEEK Filaments
Reducing Stress Shielding in Hip Implants Using 3D Printed Superelastic Titanium Alloy
Reimagining Implantable Leads: Exploring the Value of Using Aerosol Printing Technology to Replace Wire-based Structures in High-density Connections
Tailored Nanofiber Microspheres with Tunable Morphology for Accelerated Diabetic Wound Healing
The Development of Antimicrobial Ti-Cu Alloys and Understanding of their Mode of Action
Using Artifical Intelligence (AI) to Improve Medical Devices
Young Leaders International Scholar – KIM Lecture: Electrochemically Controlled Drug Delivery Valve that Exploits Crevice Corrosion

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