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Meeting 2024 TMS Annual Meeting & Exhibition
Symposium Advanced Biomaterials for Biomedical Implants
Presentation Title Optimizing the Bio-degradability and Biocompatibility of a Biogenic Collagen Membrane Through Cross-linking And Zinc-doped Hydroxyapatite
Author(s) You Wu, Shouchen Chen, Zhuofan Chen
On-Site Speaker (Planned) You Wu
Abstract Scope Biogenic collagen membranes have been widely used as barriers in GBR and GTR. Nevertheless, their clinical performance remains unsatisfactory because of their low mechanical strength and fast degradation rate. As a fundamental nutritional trace element, zinc plays an active role in promoting the growth of cells and regulating the degradation of the collagen matrix. Herein, a biogenic collagen membrane was cross-linked with glutaraldehyde-alendronate to prolong its degradation time. The physiochemical and biological properties were enhanced by the incorporation of zinc-doped nanohydroxyapatite (nZnHA). Specifically, the cross-linking combined with 1% and 2% nZnHA seemed to endow the membrane with the most appropriate biocompatibility and tissue integration capability among the cross-linked membranes, as well as offering a degradation period of six weeks in a rat subcutaneous model. Thus, improving the clinical performance of biogenic collagen membranes by cross-linking together with the incorporation of nZnHA is a promising strategy for the improvement of biogenic collagen membranes.
Proceedings Inclusion? Planned:
Keywords Biomaterials, Characterization, Composites

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Design and Application of Porous PDMS Membrane Devices in Nude Mice for Localized Treatment of Triple Negative Breast Cancer
Design and Enhancing Bbiocompatibility of β- titanium Alloy via Electro-discharge Treatment Process
Development of Antibacterial Metal Oxide Thin Films for Neurostimulation Applications via Atomic Layer Deposition
Development of Antibacterial Neural Interfacing Electrodes via Hierarchical Surface Restructuring and Atomic Layer Deposition
Enhancing Mechanical Properties of a Lightweight Biomimetic Structure by 3D Printing for Bone Tissue Engineering Application
Exploring the Microstructure of Marine Sponge Spicules: Insights for Biomimetic Bone Tissue Engineering
H-1: Bioactive Glass-ceramic Nanoparticle for Medical Implants
Hybrid Manufacturing of Superelastic Arterial Stents
Improving Free Flap Donor Site Stabilization with the Use of Additively Manufactured Custom Fixation Plates
Improvisation of Phase Stability and Texture in Biomedical Ti-based Alloys for Ultra Low Modulus Applications
In Vivo InflammatoryReaction and Elemental Trafficking of Magnesium Bioimplant Derived Aluminum
Manipulating Precipitate Population to Modulate Corrosion and Al Release in Mg-9Al Biodegradable Implants
Mechanical Integrity Testing of Bioresorbable Zn-based Alloy Under Static and Cyclic Loadings
Microstructural and Mechanical Analysis of Aerosol Jet 3D Printed Micropillars and Their Biocompatibility in Mouse Brain
Nano-biosensor to Manage COVID-19 Infection and Long-COVID
New MRI-compatible Metallic Materials for Miniaturized Implants
Novel Ti-10Mo-Mn Alloys for Biomedical Applications
Optimizing Printing Orientation for Spicule-Inspired Structures for Biomedical Applications
Optimizing the Bio-degradability and Biocompatibility of a Biogenic Collagen Membrane Through Cross-linking And Zinc-doped Hydroxyapatite
Orthopedic Patient Specific 3D Printed Implants Based on Novel Composite PEEK Filaments
Reducing Stress Shielding in Hip Implants Using 3D Printed Superelastic Titanium Alloy
Reimagining Implantable Leads: Exploring the Value of Using Aerosol Printing Technology to Replace Wire-based Structures in High-density Connections
Tailored Nanofiber Microspheres with Tunable Morphology for Accelerated Diabetic Wound Healing
The Development of Antimicrobial Ti-Cu Alloys and Understanding of their Mode of Action
Using Artifical Intelligence (AI) to Improve Medical Devices
Young Leaders International Scholar – KIM Lecture: Electrochemically Controlled Drug Delivery Valve that Exploits Crevice Corrosion

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