| About this Abstract |
| Meeting |
MS&T21: Materials Science & Technology
|
| Symposium
|
Porous Materials for Biomedical Applications
|
| Presentation Title |
P2-8: In vitro Investigation and Characterization of Resorption and Degradation Behavior of X-Ca-alginate Aerogels for Tissue Scaffold Applications |
| Author(s) |
Martina Rodriguez Sala, Grigorios Raptopoulos, Patrina Paraskevopoulou, Firouzeh Sabri |
| On-Site Speaker (Planned) |
Martina Rodriguez Sala |
| Abstract Scope |
Tissue regeneration is an intricate process facing many challenges. Studies have focused on customized-scaffolds to direct cell behavior and facilitate regeneration. Controlled biodegradability offers advantages compared to non-degradable scaffolds. Primarily, controlled resorption and degradation creates space for new tissue to grow. In the present study, polyurea-crosslinked calcium alginate aerogels (X-Ca-alginate aerogels) are investigated as a novel degradable biomaterial. Aerogels are a new class of biomaterial and recent studies have shown that not only are aerogels biocompatible but they also accelerate nerve growth and as such are highly desired as a neural prosthetic. X-Ca-alginate aerogels are biobased polymers formed by polysaccharides and strengthened though polymer-crosslinking, providing mechanically strength to support biomedical applications. To study the biomedical applications of X-Ca-alginate aerogels, extracellular matrix (ECM) proteins were used to coat the aerogel, and mammalian cells were cultured on the aerogels. The interaction between ECM, cells and X-Ca-alginate aerogels were observed and reported. |