| Author(s) |
Annabel Braem, Merve Kübra Aktan, Jef Vleugels, Bart Van Meerbeek, Wim Teughels, Isabelle François, Laurent Gremillard, Yann Chevolot, Emmanuelle Laurenceau, Mariano Sanz, Ariana Barlic, Nestor Rodriguez, Henny van der Mei, Nicolas Courtois, John Hanrahan, Melissa Courtney, Shane Keaveney, Manuela Sonja Killian, Karin Thevissen |
| Abstract Scope |
Peri-implant infections are a devastating complication of dental implants, occurring in approximately 20% of all patients. Considering the lack of predictive treatments, prevention of peri-implantitis has become a major challenge in dental implantology.
The EU-funded NOMAD project will investigate different approaches suited for Ti and ZrO2 dental implants, respectively, utilizing additive manufacturing for custom-made personalized parts as well as controlled release materials and nanotechnology for an overall biomimetic treatment modality. Biomaterials performance will be progressively validated for use in dental implants by consecutive biomechanical stability testing and complex in vitro assays up to the generation of a preclinical in vivo efficacy data set. As such, the project will proceed from TRL3 and reach TRL5, including a demonstration of production scale up and GMP as well as an economical evaluation of cost savings and patient benefits. Furthermore, a regulatory strategy will be developed in preparation of post-project exploitation paths. |