About this Abstract |
Meeting |
2022 TMS Annual Meeting & Exhibition
|
Symposium
|
Mechanical Behavior at the Nanoscale VI
|
Presentation Title |
Analyzing Lamellar Level Correlations between Mechanical Behavior and Composition in Mouse Bone |
Author(s) |
Shraddha Vachhani, Surya Kalidindi, Siddhartha Pathak |
On-Site Speaker (Planned) |
Shraddha Vachhani |
Abstract Scope |
Lamellar level correlations between the local composition and local mechanical properties in the femur of two inbred strains of mice (A/J and C57BL/6J (B6)) were studied in order to gain insights into how their extracellular matrix is mineralized. The local elastic moduli and indentation yield strengths were determined using spherical nanoindentation stress-strain analysis, while Raman spectroscopy was used to determine the local composition around the indents. Our results show a significant difference in the mineral-to-matrix ratio of the two mice strains, with the A/J mice showing an overall higher mineral-to-matrix ratio and lower carbonate substitution in the mineral. Additionally, local mineral-to-matrix ratio was found to be a good indicator of the local mechanical properties. While compositional differences are prominent in the newer bone and become less significant as the bone matured, no significant differences were observed for the correlations between mechanical behavior and composition across the two strains. |
Proceedings Inclusion? |
Planned: |
Keywords |
Biomaterials, Mechanical Properties, Characterization |