About this Abstract |
Meeting |
2022 TMS Annual Meeting & Exhibition
|
Symposium
|
Mechanical Behavior at the Nanoscale VI
|
Presentation Title |
Competing Behavior of Slip and Fracture on the Nanomechanical Response of Pharmaceutical Materials |
Author(s) |
Sushmita Majumder, Chenguang Wang, Kevin Schmalbach, Javier Garcia-Barriocanal, Greg Haugstad, Changquan Calvin Sun, Nathan Mara |
On-Site Speaker (Planned) |
Sushmita Majumder |
Abstract Scope |
In the pharmaceutical industry, crystal milling and tablet forming are two manufacturing processes that are strongly affected by the tendency for crystals to deform and/or fracture. The present investigation aims to utilize advancements in operando nanoindentation to study the influence of applied stress and environmental factors on nanomechanical behavior of single molecular crystals, L-alanine and succinic acid. Both Berkovich and spherical indenters have been used to elucidate the effects of loading geometry on mechanical behavior. We employ XRD and AFM to determine crystal orientation effects and slip/fracture features on the sample surface respectively. The observed nanomechanical behavior will be discussed in terms of existing models utilized to describe slip and fracture and can be further used to design pharmaceutical materials optimized for milling and tabletability. |
Proceedings Inclusion? |
Planned: |