About this Abstract |
Meeting |
2023 TMS Annual Meeting & Exhibition
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Symposium
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Advanced Functional and Structural Thin Films and Coatings & Honorary Palkowski Session
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Presentation Title |
A Carbon Fiber Cloth / Calcium-deficient Hydroxyapatite Biomaterial as a Promising Patch for Bone Repair |
Author(s) |
F. Olivier, N. Rochet, Sylvie Bonnamy |
On-Site Speaker (Planned) |
Sylvie Bonnamy |
Abstract Scope |
The development of a bone patch in using an activated carbon fiber cloth (ACFC) is studied. To improve ACFC biological properties, at first an uniform calcium-deficient hydroxyapatite (CDA) coating is deposited on its surface by sono-electrodeposition process. Then, cations-substituted CDA coatings were synthetized. A 3 to 7 at. % strontium substitution range is specifically analyzed. Then, we took benefit of the ACFC adsorption and the CDA bioactivity to study the adsorption capabilities and release kinetics of aspirin and tetracycline on biomimetic apatite and ACFC, then on the CDA/ ACFC biomaterial. This latter was loaded with two-drugs leading to a double adsorption functionality. In vitro biological tests allowed to analyse osteoblast viability and proliferation. In vivo experiments performed in a model of rat femoral defect allowed to investigate bone regeneration. This work highlights the possibility of bone patches with controlled (multi)drug release to be used for bone repair. |
Proceedings Inclusion? |
Planned: |