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Meeting 2023 TMS Annual Meeting & Exhibition
Symposium Functional Nanomaterials 2023
Presentation Title Second NIR-Absorbing Gelatin Stabilized Gold Nanorods with High Media and Photothermal Stability for Photothermal Cancer Therapy
Author(s) Thabang Lebepe, Samuel Oluwatobi Oluwafemi
On-Site Speaker (Planned) Samuel Oluwatobi Oluwafemi
Abstract Scope The excellent photothermal properties of gold nanorods (Au-NRs) make them one of the most researched plasmonic photothermal nanomaterials. However, their biological applications have been hampered greatly due to surfactant-induced cytotoxicity. We herein report the synthesis of highly biocompatible gelatin stabilized Au-NRs (gelatin@Au-NRs) to address this issue. The as-synthesized gelatin@Au-NRs were highly crystalline and rod-like in shape with an average length and diameter of 66.2 2.3 nm and 10 1.6 nm, respectively. The as-synthesized gelatin@Au-NRs showed high stability in common biological media (phosphate buffer saline and Dulbecco’s Modified Eagle’s Medium) compared to CTAB capped Au-NRs. Similarly, the gelatin@Au-NRs showed an improved heat production and outstanding cell viability against two different cancer cell lines; KM-Luc/GFP (mouse fibroblast histiocytoma cell line) and FM3A-Luc (breast carcinoma cell line) compared to CTAB capped Au-NRs and PEG@Au-NRs. In vitro, a photothermal therapy study against KM-Luc/GFP demonstrated the gelatin@Au-NRs are effectively destroying the cancer cells.
Proceedings Inclusion? Planned:
Keywords Biomaterials, Characterization, Nanotechnology

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