|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||Advanced Functional and Structural Thin Films and Coatings
||Doping of Biomimetic Calcium-deficient Hydroxyapatite Deposited on Activated Carbon Fiber Cloth to Improve Bone Regeneration
||Florian Olivier, Nathalie Rochet, Sylvie Bonnamy
|On-Site Speaker (Planned)
In previous study we shown that sono-electrodeposition process can be optimized to coat activated carbon fiber cloth (ACC) with carbonated calcium-deficient hydroxyapatite (CDA). In the present study, this process is used to dope CDA coatings in performing calcium substitution with cations such as strontium, manganese and gallium. Cations-substituted CDA coatings were synthetized and quantitatively controlled up to 10 at.%. In this range, the presence of substitution does not modify the microtexture and slightly modified the crystallographic structure. Especially for the strontium-substituted CDA, the biocompatibility of the materials was tested using primary human osteoblasts. It revealed a positive and dose-dependent effect of strontium addition on osteoblast activity and proliferation. In vivo experiments were performed in a model of rat femoral defect to investigate bone regeneration. Results revealed the high biocompatibility of Sr-substituted CDA/ACC biomaterials and highlighted their efficacy to accelerate the bone defect reconstruction by simple apposition on the wounded zone.
||Biomaterials, Surface Modification and Coatings, Characterization