Diffusion mobility databases are one of the foundations for computational kinetics simulations of materials processes such as solidification, precipitation, and creep deformation. Even though mobility databases have been established for several alloy systems such as Al alloys, Fe alloys, Mg alloys, Ni alloys, and Ti alloys; there is still substantial room for improvement of the accuracy of these databases. New mobility databases are also needed for new alloy systems and for multicomponent high-entropy alloys. This talk will explain holistic approaches to reliably and efficiently establish new mobility databases as well as improving the existing mobility databases. Ways to holistically integrate both experimental and computed data will be explained with a call for more computed data.