Molten chloride and fluoride salt fast reactors (MSR) are under active development because they offer several operational and safety advantages over other types of reactors. Modern designs require structural materials with superior corrosion, creep, thermomechanical fatigue, irradiation damage and Helium bubble and tellurium-induced grain boundary embrittlement resistance to high temperatures of 750-950°C. Nickel-base alloys generally perform better than all other alloys studied to date, though none yet have the set of property requirements to meet these demanding conditions. In this talk, I will report on the development of the next generation of nickel-base alloys for MSRs utilizing an ICME approach combined with a detailed experimental processing, testing, characterization and modeling program. Results of the alloy design strategy, phase equilibria and transformations and evolution of microstructure and high temperature mechanical properties will be presented and discussed. The irradiation and corrosion behavior in molten chloride salt of selected alloys will also be presented. Future directions will be discussed.