Novel materials with improved performance and advanced application fit property profiles such as lightweight, thermal stability, high-temperature strength, and good oxidation resistance can be designed within the framework of the vast compositional space available in high entropy alloys (HEAs). The study is to design nickel-aluminide (Ni-Al) based high-entropy alloys for lightweight, high strength, and high-temperature applications using a CALPHAD-based tool and thermodynamic physical parameters such as mixing entropy, mixing enthalpy, and valence electron concentration (VEC) to design the right match of multi principal elements. The study will establish the use of Thermo-Calc software to perform thermodynamic modelling of the phases present, phase diagrams, and transformation temperatures. The Thermo-Calc software will be used to access the necessary databases for kinetic and thermodynamic calculations for the nickel aluminide-based HEAs. The study aims to design novel HEAs based on nickel that may replace the superalloys in aero-engines.