Additive manufacturing (AM) of metals is to build metallic components through layer-by-layer that can make the prepared materials with unique geometries. Due to the rapid solidification and high cooling rates during AM process, the microstructure within AM metals has unique features, such as interlayer interfaces, molten pool solidification boundaries and intracrystalline substructure. It is critical to understand the relationship between the spatial heterogeneity of the microstructure and the mechanical properties of AM metals. In this work, discrete dislocation dynamics (DDD) simulations will be used to explore the effect of dislocation cells on the strength and anisotropy of the AM metals. In our DDD simulations, we will vary the dislocation cell size, dislocation density within the cell walls and loading directions to explore how these factors affect the dislocation behavior within the dislocation cells. In addition, our model will also consider the influence of solute concentrations.