| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advances in Biomaterials for 3D Printing
|
| Presentation Title |
Investigation of Cell Sedimentation in Inkjet-based Bioprinting of Cell-Laden Bioink |
| Author(s) |
Heqi Xu, Jazzmin Casillas, Srikumar Krishnamoorthy, Changxue Xu |
| On-Site Speaker (Planned) |
Heqi Xu |
| Abstract Scope |
Inkjet-based bioprinting has been widely used for various applications in tissue engineering and regenerative medicine. The bioink used is considered as a suspension incorporating living cells. Because the typical bioprinting process may take several hours, the suspended cells in the bioink sediment with time, which significantly affects the bioink stability as well as the following printing accuracy and reliability. This study investigates the effects of polymer concentration and standing time on the cell sedimentation velocity and cell concentration, and the effect of cell sedimentation on the cell distribution within droplets. The results show that the cell sedimentation velocity is almost constant at different standing times, and with the increase of the polymer concentration the cell sedimentation velocity decreases. It is also seen that the cell gravitational force may change, because water flows into cells through the mechanism of osmosis due to concentration gradient of solute across the cell membrane. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |