|About this Abstract
||MS&T22: Materials Science & Technology
||Society for Biomaterials: Biomaterial Applications in Today’s Industry: Development, Translation & Commercialization
||Silicon Nitride-infused Fabrics Exhibit Antiviral Behavior
||Brittany Heath, Chelsey McMinn, Sherry M. Van Mondfrans, Jackson Hendry, Sean Ronayne, Douglas M. Hoxworth, B. Sonny Bal, Bryan J. McEntire, Kylene Kehn-Hall, Ryan M. Bock
|On-Site Speaker (Planned)
||Ryan M. Bock
Active anti-microbial agents capable of inactivating a wide range of pathogens without presenting toxicity hazards are needed for use in durable and reusable medical personal protective equipment. Silicon nitride, a ceramic commercialized as a spinal implant material, has previously demonstrated antibacterial and antifungal activity in a monolithic form. In this study, α- and β-phase silicon nitride powders were subjected to physicochemical characterization, cytotoxicity testing using Vero cells, and a viral inactivation assay based on the ISO 18184 protocol using SARS-CoV-2. Spunbond polypropylene fabrics infiltrated with α-silicon nitride were also characterized and subjected to the same cytotoxicity and viral inactivation protocols. A concentration- and exposure time-dependent antiviral response was observed for both powders, which did not exhibit evidence of cytotoxicity at concentrations below 20% (w/v). Nitride-infiltrated fabric also demonstrated antiviral behavior that intensified as powder loading and exposure time were increased.