Recent advancements in manufacturing have provided unprecedented opportunities to produce materials with precisely defined architectures. This has in turn has provided opportunities to achieve new combinations of material properties, and ultimately re-think the design of material structures as well as the components and structures in which they are used. The computational design tool of topology optimization is particularly well-suited to address this new design challenge. Topology optimization systematically adds/removes material from the design domain computationally, thereby enabling discovery of new, high performance structures. This freedom, however, may produce designs that are topologically complex, making them difficult and expensive to manufacture. This talk will discuss the use of topology optimization in the design of architected materials optimized for various properties, including mechanical, thermal, and fluidic, and discuss the integration of manufacturing considerations into the design process, ultimately leading to architected material designs that are both high performance and manufacturable.