| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Porous, Freeze-cast Fluorohydroxyapatite and Hydroxyapatite-titania Composites for Biomedical Applications |
| Author(s) |
Tony J. Yin, Sujee Jeyapalina, Steven E. Naleway |
| On-Site Speaker (Planned) |
Tony J. Yin |
| Abstract Scope |
New bone substitutes are needed to meet the increasing demand for orthopedic and dental reconstruction needs. These substitutes require a porous structure to allow for vascularization, specific mechanical properties to provide structural strengths, and biocompatibility to prevent excessive immune responses and to improve new bone formation. Porous fluorohydroxyapatite and hydroxyapatite-titania scaffolds made through freeze casting were studied for use as bone substitutes. By combining the freeze casting technique with different modifications to hydroxyapatite, scaffolds with improved mechanical properties can be achieved. Scaffolds made with these materials showed mechanical strengths comparable to trabecular bone and favorable in vitro osteoblast proliferation. In addition, efforts to infiltrate the freeze-cast scaffolds with biologic adjuvants in polymeric matrix coating for enhancing bone repair led to an autograft-like scaffold. These techniques show how next-generation bone substitutes can be fabricated by tailoring the porous structured scaffold and enhancing it with the biologics necessary for improving bone ingrowth. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Ceramics, Composites |